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Vitamin K Could Boost Bone Health

Posted May 1, 2006

Bone mineral density may be improved by adding vitamin K2 to calcium supplementation.

Scientists in Indonesia conducted a study to investigate the effect of vitamin K2 (menatetrenone) treatment on bone mineral density (BMD) and a bone metabolic marker (osteocalcin) in postmenopausal women with osteoporosis living in Indonesia. They performed a double-blind randomized placebo-controlled study of 63 postmenopausal women with osteoporosis.

The vitamin K2 group received 45 mg menatetrenone and 1500 mg calcium carbonate per day and the control group received placebo and 1500 mg calcium carbonate per day for 48 weeks, explained Y. Purwosunu and colleagues of the University of Indonesia. BMD of lumbal spine (L2-L4), osteocalcin (OC) and undercarboxylated OC were measured before, 24 and 48 weeks after initiation of the treatment.

They reported after 48 weeks of treatment, the mean percentage change of lumbar BMD in the vitamin K2 group was significantly higher than that of the control group. The undercarboxylated OC level decreased by 55.9% in the menatetrenone group and 9.3% in the control group compared with the baseline level.

The authors noted the difference between the two groups was significant. The adverse events were three minor gastrointestinal cases, which subsided after temporary cessation of therapy.

Treatment with 45 mg vitamin K2 with 1500 mg calcium per day for postmenopausal women with osteoporosis for 48 weeks resulted in a significant increase in lumbar BMD and a significant decrease in undercarboxylated OC levels concluded the researchers.

Purwosunu and colleagues published their study in the Journal of Obstetrics and Gynaecology Research (Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. J Obstet Gynaecol Res, 2006;32(2):230-234).

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Date: April 29, 2006

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