If you are currently being treated with any of the following medications, you
should not use zinc without first talking to your healthcare provider.
Blood Pressure Medications, ACE Inhibitors
A class of
medications called ACE Inhibitors, such as captopril and enalpril, used for high
blood pressure may deplete zinc stores.
Zinc may decrease the absorption of oral
quinolones, a class of antibiotics that includes ciprofloxacin, norfloxacin,
ofloxacin, and levofloxacin, as well as tetracycline antibiotics (including
tetracycline, doxycycline, and minocycline).
Hormone Replacement Therapy (HRT)
HRT, consisting of estrogen
and progesterone derivatives may reduce loss of zinc in the urine, particularly
in women with osteoporosis.
There has been at least one report of an
interaction between zinc and hydralazine, a medication used to treat high blood
pressure, which resulted in a lupus-erythematosus-like syndrome (characterized
by a facial butterfly rash, fever, leg and mouth ulcers, and abdominal
Since zinc supports immune
function, it should not be taken with corticosteroids, cyclosporine, or other
medications intended to suppress the immune system.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
with NSAIDs and could reduce the absorption and effectiveness of these
medications. Examples of NSAIDs, which help to reduce pain and inflammation,
include ibuprofen, naprosyn, piroxicam, and indomethacin.
This medication, used to treat Wilson's disease
(excessive amounts of copper that accumulate in the brain, liver, kidney, and
eyes) and rheumatoid arthritis, decreases zinc levels.