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Table of Contents > Supplements > Vitamin B1 (Thiamine) > Interactions
Possible Interactions with: Vitamin B1 (Thiamine)
Also listed as: Thiamine

If you are currently being treated with any of the following medications, you should not use vitamin B1 without first talking to your healthcare provider.

Antibiotics, Tetracycline
Vitamin B1 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B1 either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

Antidepressant Medications, Tricylic
Taking vitamin B1 supplements may improve treatment with antidepressants such as nortriptyline, especially in elderly patients. Other medications in this class of antidepressants include desimpramine and imipramine.

Although the significance is not entirely clear, laboratory studies suggest that thiamine may inhibit the anti-cancer activity of chemotherapy agents. How this will ultimately prove relevant to people is not known. However, it may be wise for people undergoing chemotherapy for cancer to not take large doses of vitamin B1 supplements.

Laboratory studies suggest that digoxin (a medication used to treat heart conditions) may reduce the ability of heart cells to absorb and use vitamin B1; this may be particularly true when digoxin is combined with furosemide (a loop diuretic).

Diuretics (particularly furosemide, which belongs to a class called loop diuretics) may reduce the levels of vitamin B1 in the body. In addition, similar to digoxin, furosemide may diminish the heart's ability to absorb and utilize vitamin B1, especially when these two medications are combined.

Vitamin B1 may help reduce some of the side effects associated with scopolamine, a medication commonly used to treat motion sickness.

Drug Interactions
Scopolamine-containing Medications
Tricyclic Antidepressants

Copyright © 2004 A.D.A.M., Inc

The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.

Vitamin B1 (Thiamine)
  Uses of this Supplement
Alzheimer's Disease
Congestive Heart Failure
  Supplements with Similar Uses
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  Drugs that Interact
Scopolamine-containing Medications
Tricyclic Antidepressants
  Drugs that Deplete this Substance
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  Supplements with Similar Side Effects
View List by Side Effect
  Supplements with Similar Warnings
View List by Warning
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