If you are currently being treated with any of the following medications, you
should not use psyllium supplements without first talking to your healthcare
Antidepressant Medications, Tricyclics
Dietary fiber has been
shown to lower the blood levels and effectiveness of tricyclic antidepressant
medications such as amitriptyline, doxepin, and imipramine in three patients.
Reduced dietary fiber intake increased the blood levels and improved symptoms in
these patients. Individuals taking tricyclic medications should consult a
healthcare provider before increasing psyllium intake.
Taking psyllium with carbamazepine, a medication
used to treat seizure disorders, may decrease the absorption and effectiveness
of carbamazepine. If taking psyllium and carbamazepine, blood levels of
carbamazepine should be monitored closely by a healthcare provider.
Cholesterol-lowering Medications, Bile Acid
Combining psyllium with the cholesterol-lowering
medications classified as bile acid sequestrants, such as cholestyramine or
colestipol, may be beneficial in lowering cholesterol levels and may reduce side
effects of colestipol. Consult with your healthcare practitioner about whether
this may be an option for you.
While fiber supplements may help to
regulate blood sugar levels, they may also interfere with the absorption of
anti-diabetic medications, specifically glyburide and metformin. Therefore,
fiber supplements should not be taken at the same time as these drugs.
Fiber supplements may reduce the body's ability to
absorb digoxin, a medication used to regulate heart function. Therefore, it is
likely that psyllium and psyllium supplements would similarly interfere with the
absorption of digoxin and should not be taken at the same time as this
Reports suggest that psyllium may lower lithium levels
in the blood, reducing the effectiveness of this medication. If both are used,
they should be taken at least one hour apart, preferably two. Lithium levels
should be monitored very closely by a healthcare provider, particularly if there
is any significant change in fiber intake.