Possible Interactions with: Vitamin B12 (Cobalamin)

Possible Interactions with: Vitamin B12 (Cobalamin)
Also listed as: Cobalamin; Cyanocobalamin

If you are currently being treated with any of the following medications, you should not use vitamin B12 supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline
Vitamin B12 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B12 either alone or in combination with other B vitamins should be taken at different times of the day from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.

Anti-ulcer Medications
The body's ability to absorb vitamin B12 is decreased when taking stomach acid-reducing medications such as omeprazole, lansoprazole, ranitidine, cimetidine, or antacids that are often used to treat gastroesophageal reflux, ulcers or related symptoms. This interference is most likely to occur as a result of prolonged use (more than one year) of these medications.

Chemotherapy Medications
Blood levels of vitamin B12 may be reduced when taking chemotherapy medications (particularly methotrexate) for cancer.

Metformin for diabetes
Blood levels of vitamin B12 may also be reduced when taking metformin for diabetes.

Phenobarbital and Phenytoin
Long-term treatment with either phenobarbital and phenytoin for seizure disorders may interfere with the body's ability to use vitamin B12.

Drug Interactions
Antiulcer Medications
Metformin-containing Medications
Phenobarbital-containing Medications
Phenytoin-containing Medications

Copyright © 2004 A.D.A.M., Inc

The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.

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