Possible Interactions with: Iron

Possible Interactions with: Iron
Also listed as: Ferrous Sulfate

If you are currently being treated with any of the medications discussed below, you should not use iron without first talking to your healthcare provider.

Iron may interfere with the absorption of many different medications. For this reason, it is best to take iron supplements at least two hours before or two hours after taking medications. This is particularly true for the medications listed below.

The following medications may reduce the absorption of iron:

  • Cholestyramine and Colestipol: These are two cholesterol-lowering medications known as bile acid sequestrants.
  • Medications used to treat ulcers or other stomach problems: Examples of anti-ulcer medications include cimetidine, ranitidine, famotidine, and nizatidine. These medications belong to a class of drugs known as H2 receptor blockers. They change the pH in the stomach and subsequently alter the absorption of iron. It is possible that this effect could occur with other antiulcer medications including antacids and proton pump inhibitors (such as omeprazole and lansoprazole).

Iron decreases the absorption of the following medications:

  • Tetracyclines: These are a class of antibiotics that include doxycycline, minocycline, and tetracycline.
  • Quinolones: These are a class of antibiotics that include ciprofloxacin, norfloxacin, ofloxacin, and levofloxacin.
  • ACE inhibitors: These are a class of medications used to treat high blood pressure. Examples include captopril, enalapril, and lisinopril.

Iron may reduce the effectiveness or blood levels of the following medications:

  • Carbidopa and Levodopa: Iron lowers blood levels of these medications but it is unclear whether these changes lower the effectiveness of the drugs.
  • Levothyroxine: Iron may decrease the effectiveness of this thyroid replacement hormone. A healthcare practitioner should monitor thyroid function closely in those taking iron supplements with thyroid medications.

Iron levels may be increased by:

  • Birth control medications 

Drug Interactions
ACE Inhibitors
Bile Acid Sequestrants
Birth Control Medications
Proton-pump Inhibitors
Ranitidine Bismuth Citrate

Copyright © 2004 A.D.A.M., Inc

The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.

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