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Table of Contents > Supplements > Magnesium > Interactions
Possible Interactions with: Magnesium

If you are currently being treated with any of the following medications, you should not use magnesium without first talking to your healthcare provider.

Antibiotics
The absorption of quinolone antibiotics (such as ciprofloxacin and moxofloxacin), tetracycline antibiotics (including tetracycline, doxycycline, and minocycline), and nitrofurantoin is diminished when taken with magnesium supplements. Therefore, magnesium should be taken two to four hours before or after taking these medications to avoid interference with absorption.

Blood Pressure Medications, Calcium Channel Blockers
Magnesium may increase the likelihood of negative side effects (such as dizziness, nausea, and fluid retention) from calcium channel blockers (particularly nifedipine) in pregnant women. Other calcium channel blockers include amlodipine, diltiazem, felodipine, and verapamil.

Diabetic Medications
Magnesium hydroxide, commonly found in antacids, may increase the absorption of glipizide and glyburide, medications used to control blood sugar levels. Ultimately, this may prove to allow for reduction in the dosage of those medications.

Digoxin
It is important that normal levels of magnesium be maintained while taking digoxin because low blood levels of magnesium can increase adverse effects from this drug. In addition, digoxin can lead to increased loss of magnesium in the urine. A healthcare provider will follow magnesium levels closely to determine whether magnesium supplementation is necessary.

Diuretics
Two types of diuretics known as loop (such as furosemide) and thiazide (including hydrochlorothiazide) can deplete magnesium levels. For this reason, physicians who prescribe diuretics may consider recommending magnesium supplements as well.

Hormone Replacement Therapy for menopause
Magnesium levels tend to decrease during menopause. Studies suggest, however, that hormone replacement therapy may help prevent the loss of this mineral. Postmenopausal women or those taking hormone replacement therapy should talk with a healthcare provider about the risks and benefits of magnesium supplementation.

Levothyroxine
There have been case reports of magnesium containing antacids reducing the effectiveness of levothyroxine, which is taken for an under active thyroid. This is important because many people take laxatives containing magnesium without letting their doctor know.

Penicillamine
Penicillamine, a medication used for the treatment of Wilson's disease (a condition characterized by high levels of copper in the body) and rheumatoid arthritis, can inactivate magnesium, particularly when high doses of the drug are used over a long period of time. Even with this relative inactivation, however, supplementation with magnesium and other nutrients by those taking penicillamine may reduce side effects associated with this medication. A healthcare practitioner can determine whether magnesium supplements are safe and appropriate if you are taking penicillamine.

Tiludronate and Alendronate
Magnesium may interfere with absorption of tiludronate, a medication similar to alendronate that is used for the treatment of osteoporosis. This interaction has not been reported with alendronate specifically. Magnesium supplements or magnesium-containing antacids should be taken at least two hours before or two hours after taking these medications to minimize potential interference with absorption.

Others
Aminoglycoside antibiotics (such as gentamicin and tobramycin), thiazide diuretics (such as hydrochlorothiazide), loop diuretics (such as furosemide and bumetanide), amphotericin B, corticosteroids, antacids, and insulin may lower magnesium levels. Please refer to the depletions monographs on some of these medications for more information.


Drug Interactions
Alendronate
Antibiotics
Calcium-channel Blockers
Corticosteriod Medications
Digoxin
Diuretics
Glipizide
Glyburide
Hormone Replacement Therapy (HRT)
Insulin
Levothyroxine
Loop Diuretics
Thiazide Diuretics
Tiludronate

Copyright © 2004 A.D.A.M., Inc

The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.

 
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Magnesium
  Uses of this Supplement
Asthma
Atherosclerosis
Attention Deficit/Hyperactivity Disorder
Chronic Obstructive Pulmonary Disease
Diabetes Mellitus
Fibromyalgia
HIV and AIDS
Hypertension
Menopause
Migraine Headache
Myocardial Infarction
Osteoporosis
Preeclampsia
Premenstrual Syndrome
Stroke
Ulcerative Colitis
  Supplements with Similar Uses
View List by Use
  Drugs that Interact
Summary
Alendronate
Antibiotics
Calcium-channel Blockers
Corticosteriod Medications
Digoxin
Diuretics
Glipizide
Glyburide
Hormone Replacement Therapy (HRT)
Insulin
Levothyroxine
Loop Diuretics
Thiazide Diuretics
Tiludronate
  Drugs that Deplete this Substance
View List
  Supplements with Similar Side Effects
View List by Side Effect
  Supplements with Similar Warnings
View List by Warning
  Related Articles
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Nutrition
 

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