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Table of Contents > Supplements > 5-Hydroxytryptophan (5-HTP) > Interactions
Possible Interactions with: 5-Hydroxytryptophan (5-HTP)
Also listed as: 5-HTP

If you are currently being treated with any of the following medications, you should not use 5-HTP without first talking to your healthcare provider.

Antidepressant Medications

Individuals taking the antidepressant medications known as selective serotonin reuptake inhibitors (SSRIs) (such as fluoxetine, paroxetine, sertraline, and citalopram) and monoamine oxidase inhibitors (MAOIs) (such as phenelzine, isocarboxazid, selegiline, and tranylcypromine) should not use 5-HTP as these medications enhance the action of these drugs and may increase the risk for developing a dangerous condition known as "serotonin syndrome." Serotonin syndrome is characterized by mental status changes, rigidity, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma. Similarly, other drugs for depression that interfere with the uptake of the neurotransmitter serotonin, namely trazodone and venlafexine, may also lead to serotonin syndrome when used along with 5-HTP.


Taking 5-HTP with carbidopa, a medication used to treat Parkinson's disease, has been associated with side effects including scleroderma-like illnesses (a condition in which the skin becomes hard, thick, and inflamed).

Similar to antidepressants, sumatriptan, a medication used for migraine headaches that works by stimulating serotonin receptors in the brain, should also not be used in combination with 5-HTP because of the risk for serotonin syndrome.


Tramadol, used for pain control, may also increase serotonin levels too much if taken in combination with 5-HTP. Serotoninsyndrome has been reported in some people taking the two together.


Use of zolpidem, a medication for insomnia, can cause hallucinations when used with SSRI antidepressants. Because 5-HTP may work similarly to SSRIs, the combination of 5-HTP with zolpidem could, theoretically, lead to hallucinations as well.

Drug Interactions
Antidepressant Medications
MAO Inhibitors
Selective Serotonin Reuptake Inhibitors (SSRIs)
Sumatriptan Succinate

Copyright © 2004 A.D.A.M., Inc

The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.

5-Hydroxytryptophan (5-HTP)
  Uses of this Supplement
Diabetes Mellitus
Migraine Headache
  Supplements with Similar Uses
View List by Use
  Drugs that Interact
Antidepressant Medications
MAO Inhibitors
Selective Serotonin Reuptake Inhibitors (SSRIs)
Sumatriptan Succinate
  Supplements with Similar Side Effects
View List by Side Effect
  Supplements with Similar Warnings
View List by Warning
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