Richard's Whole Foods  
10% Off Register online today and receive 10% off your next in-store purchase.
Your E-mail:     
Healthy Recipes Reference Library Store Specials About Us Friday, May 05, 2006
Search Site
Departments
Reference Library
  
Sign In
My Account
Contact Us
Shopping Cart
Checkout
Help


 
 
Table of Contents > Herbs > Gotu Kola
Gotu Kola
Botanical Name:  Centella asiatica
Common Names:  Centella, March Pennywort, Indian Pennywort, Hydrocotyle, Brahmi (Sanskrit), Luei Gong Gen (Chinese)(Note: Gotu kola should not be confused with kola nut.)
 
Overview
Plant Description
Medicinal Uses and Indications
Dosage and Administration
Precautions
Interactions and Depletions
Supporting Research

Overview

Gotu kola has been used as a medicinal herb for thousands of years in India, China and Indonesia. Its ability to heal wounds, improve mental clarity, and treat skin conditions such as leprosy and psoriasis were important reasons for its extensive use in these countries. It has also been called one of the "miracle elixirs of life" because legend has it that an ancient Chinese herbalist lived for more than 200 years as a result of using the herb.

Historically, gotu kola has also been used to treat syphilis, hepatitis, stomach ulcers, mental fatigue, epilepsy, diarrhea, fever, and asthma. Today, American and European herbalists use gotu kola for disorders that cause connective tissue swelling, such as scleroderma, psoriatic arthritis (arthritis occurring in conjunction with psoriasis), anklylosing spondylitis (arthritis of the spine), and rheumatoid arthritis. Recent studies confirm some of the traditional uses and also suggest possible new applications for gotu kola, such as lowering high blood pressure, treating venous insufficiency (pooling of blood in the veins, usually in the legs, boosting memory and intelligence, easing anxiety, and speeding wound healing.

Gotu kola should not be confused with kola nut (Cola nitida). Kola nut is an active ingredient in Coca Cola and contains caffeine. Gotu kola has no caffeine, and is not a stimulant.


Plant Description

Gotu kola is a perennial plant native to India, Japan, China, Indonesia, South Africa, Sri Lanka, and the South Pacific. It is a tasteless, odorless plant that thrives in and around water. It has small fan-shaped green leaves with white or light purple-to-pink flowers and it bears small oval fruit. The leaves and stems of the gotu kola plant are used for medicinal purposes.


Medicinal Uses and Indications
Treatment

Wound Healing and Skin Lesions

Gotu kola contains triterpenoids, compounds that have been shown to aid in wound healing. For example, animal studies indicate that triterpenoids strengthen the skin, increase the concentration of antioxidants in wounds, and restore inflamed tissues by increasing blood supply. Because of these properties, gotu kola has been used externally for burns, psoriasis, prevention of scar formation following surgery, recovery from an episiotomy following vaginal delivery of a newborn, and treatment of external fistulas (a tear at or near the anus).

Venous Insufficiency and Varicose Veins

When blood vessels lose their elasticity, blood pools in the legs and fluid leaks out of the blood vessels, causing the legs to swell (venous insufficiency). In a study of 94 people with venous insufficiency, those who took gotu kola reported a significant improvement in symptoms compared to those who took placebo. In another study of people with varicose veins, ultrasound examination revealed improvements in the vascular tone of those who took gotu cola.

High Blood Pressure

In a study of people with heart disease and high blood pressure, those who took abana (an Ayurvedic herbal mixture containing gotu kola) experienced a significant reduction in diastolic blood pressure (pressure on blood vessels when the heart is at rest) compared to those who took placebo. Further studies are needed to determine whether gotu kola alone, some other herb in the Ayurvedic mixture, or the particular combination of all the herbs in the remedy is responsible for the beneficial effect.

Anxiety

Triterpenoids(active compounds in gotu kola) have been shown to soothe anxiety and boost mental function in mice.A recent study found that people who took gotu kola were less likely to be startled by a novel noise (a potential indicator of anxiety) than those who took placebo. Although the results of this study are somewhat promising, the dose used in this study was extremely high, making it difficult to draw any conclusions about how gotu kola might be used by people with anxiety.

Scleroderma

One study involving 13 females with scleroderma found that gotu kola decreased joint pain, skin hardening, and improved finger movement.

Insomnia

Because of sedative effects demonstrated in animals, gotu kola has been used to help people with insomnia.


Dosage and Administration

Gotu kola is available in teas, as dried herbs, tinctures, capsules, tablets, and ointments. It should be stored in a cool, dry play and used before the expiration date on the label.


Pediatric

There is currently no information in the scientific literature about the use of gotu kola for children. Therefore, it is not recommended for those under 18 years old.


Adult

The adult dosage of gotu kola may vary depending on the condition being treated. An appropriately trained and certified herbalist, such as a naturopath, can provide the necessary guidance.

The standard dose of gotu kola varies depending on the form:

  • Dried herb—to make tea, add to tsp dried herb to a cup of boiling water (150 mL) for 10 minutes, 3 times a day
  • Powdered herb (available in capsules)—1,000 to 4,000 mg, 3 times a day
  • Tincture (1:2, 30% alcohol)—30 to 60 drops (equivalent to 1.5 to 3 mL - there are 5 mL in a teaspoon), 3 times a day
  • Standardized extract—60 to 120 mg per day; standardized extracts should contain 40% asiaticoside, 29% to 30% asiatic acid, 29% to 30% madecassic acid, and 1% to 2% madecassoside; doses used in studies mentioned in the treatment section range from 20 mg (for scleroderma) up to 180 mg (in one study for venous insufficiency; although, most of the studies for this latter condition were conducted using 90 mg to 120 mg per day).

The recommended dosage for people with insomnia is tsp of dried herb in a cup of water taken for no more than 4 to 6 weeks.


Precautions

The use of gotu kola for more than 6 weeks is not recommended. People taking the herb for an extended period of time (up to 6 weeks) should take a 2-week break before taking the herb again.

Asiaticoside, a major component of gotu kola, has also been associated with tumor growth in mice. Though more studies are needed, it is wise for anyone with a history of precancerous or cancerous skin lesions—such as squamous cell, basal cell skin cancer, or melanoma—to refrain from taking this herb.


Side Effects

Side effects are rare but may include skin allergy and burning sensations (with external use), headache, stomach upset, nausea, dizziness, and extreme drowsiness. These side effects tend to occur with high doses of gotu kola.


Pregnancy and Breastfeeding

Pregnant women should not take gotu kola because it may cause spontaneous abortion. There is little or no information regarding the safety of this herb during breastfeeding, so nursing mothers should refrain from taking this herb.


Pediatric Use

Gotu kola is not recommended for children.


Geriatric Use

People older than 65 years should take gotu kola at a lower than standard dose. The strength of the dosage can be increased slowly over time to reduce symptoms. This is best accomplished under the guidance of an appropriately trained and certified herbalist such as a naturopathic doctor.


Interactions and Depletions

There have been no reports documenting negative interactions between gotu kola and medications to date. Since high doses of gotu kola can cause sedation, individuals should refrain from taking this herb with medications that promote sleep or reduce anxiety.


Supporting Research

Antani JA, Kulkarni RD, Antani NJ. Effect of abana on ventricular function in ischemic heart disease. Jpn Heart J. Nov 1990: 829-835.

Anonymous. Centella asiatica (Gotu kola). Botanical Monograph. American Journal of Natural Medicine. 1996;3(6):22-26.

Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA. Angiology. 1990;41(1):12-18.

Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J ClinPsychopharmacol. 2000;20(6):680-684.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publication; 1998.

Brinkhaus B, Linder M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomed. 2000;7(5):427-448.

Cauffield JS, Forbes HJM. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Lippincotts Prim Care Pract. 1999:3(3):290-304.

DerMarderosian A, ed. Gotu Kola. In: Facts and Comparisons The Review of Natural Products. St. Louis, MO: Wolters Kluwer Co.: 1999:1-3.

Fetrow C, Avila J. Professional's Handbook of Complementary & Alternative Medicines. Springhouse, PA: Springhouse Corp.; 1999.

Gruenwald J, Brendler T, Jaenicke C, Fleming T, Deutsch M, Hamid M, eds. et al. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc..; 1998:729-731.

Kuhn M, Winston D. Herbal Therapy and Supplements: A Scientific and Traditional Approach. Philadelphia, Pa: Lippincott; 2001.

McCaleb R. Anti-Cancer Effects of Gotu Kola. HerbalGram. 1996;36:17.

McGuffin M, Hobbs C, Upton R, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press; 1997.

Miller LG, Murray W J, eds. Herbal Medicinals: A Clinician Guide. New York, NY: Pharmaceutical Products Press; 1998:217.

Peirce A. Practical Guide to Natural Medicines. New York: Stonesong Press Inc.; 1999:317-318.

Pointel JP, Boccalon H, Cloarec M, Ledevehat C, Joubert M. Titrated extract of centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology 1987;38(1 Pt 1):46-50.

Russo E. Handbook of Psychotropic Herbs. New York, NY: Hawthorn Herbal Press; 2001.

Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res. 1999;13(1):50-54 [abstract].


Review Date: March 2001
Reviewed By: Participants in the review process include: Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley Hospital, Harvard University and Senior Medical Editor Integrative Medicine, Boston, MA; Gary Kracoff, RPh (Pediatric Dosing section February 2001), Johnson Drugs, Natick, MA; Steven Ottariono, RPh (Pediatric Dosing section February 2001), Veteran's Administrative Hospital, Londonderry, NH; David Winston, Herbalist, Herbalist and Alchemist, Inc., Washington, NJ.

Copyright © 2004 A.D.A.M., Inc

The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.

 
RELATED INFORMATION
  Uses of this Herb
Anxiety
Atherosclerosis
Burns
Fibromyalgia
Hypertension
Insomnia
Psoriasis
Radiation Damage
Scleroderma
Varicose Veins
Wounds
  Herbs with Similar Uses
View List by Use
  Drugs that Interact
Summary
  Herbs with Similar Side Effects
View List by Side Effect
  Herbs with Similar Warnings
View List by Warning
  Related Articles
View Articles
  Learn More About
Herbal Medicine
 

Home | Store Locations | Buy Online | Store Specials | About Us | Delicious Living | Reference Library | News & Features | Health Tools | Treatment Options | Healthy Recipes | Ingredient Glossary | My Account | Contact Us | Help | Shopping Cart | Privacy Policy | Terms of Use |



Powered By Living Naturally