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Table of Contents > Drugs >  Selegiline
Selegiline
Pronunciation
Brand Names
Foreign Brand Names
Therapeutic Categories
Reasons not to take this medicine
What is this medicine used for?
How does it work?
How is it best taken?
What do I do if I miss a dose?
What are the precautions when taking this medicine?
What are the common side effects of this medicine?
What should I monitor?
Reasons to call healthcare provider immediately
How should I store this medicine?
General statements

Pronunciation
(seh LEDGE ah leen)

Brand Names
Atapryl®; Eldepryl®; Selpak®

Foreign Brand Names
Novo-Selegiline (Canada)

Therapeutic Categories
Antidepressant, Monoamine Oxidase Inhibitor; Anti-Parkinson's Agent (Monoamine Oxidase Inhibitor)

Reasons not to take this medicine

  • If you have an allergy to selegiline or any other part of the medicine.
  • If you are taking meperidine.


What is this medicine used for?

  • This medicine is used for the treatment of early symptoms of Parkinson's disease.


How does it work?

  • Selegiline increases a chemical in the brain called dopamine. There may be low amounts of dopamine in the system.


How is it best taken?

  • Take with breakfast and lunch.
  • Take early in the day to avoid sleep problems.


What do I do if I miss a dose?

  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
  • Do not take a double dose or extra doses.


What are the precautions when taking this medicine?

  • Avoid alcohol (includes wine, beer, and liquor). Could worsen side effects.
  • If you are on a high dose (10 mg per day), avoid tyramine-containing foods. These would include aged meats and cheeses, soy sauce, certain beans, sauerkraut, beer, concentrated fungus (yeast) extracts, and others. Talk with healthcare provider.
  • Do not use this medicine with monoamine oxidase inhibitors. These include isocarboxazid, phenelzine, and tranylcypromine. Separate use by 2 weeks.
  • Use caution if you have high blood pressure. Talk with healthcare provider.
  • Do not use over-the-counter products that may affect blood pressure. These include cough or cold remedies, diet pills, stimulants, ibuprofen or like products, certain herbs or supplements. Talk with healthcare provider.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.


What are the common side effects of this medicine?

  • Feeling lightheaded or faint. Avoid driving, doing other tasks or activities that require you to be alert until you see how this medicine affects you.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard candy, or chewing gum may help.
  • Dizziness is common. Rise slowly over several minutes from sitting or lying position. Be careful climbing stairs.


What should I monitor?

  • Check blood pressure regularly.
  • Watch for symptoms of Parkinson's disease. Are they better, worse, or about the same?


Reasons to call healthcare provider immediately

  • Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat.
  • Very nervous and excitable.
  • Changes in balance, feeling shaky or unsteady.
  • Passing out, fainting, dizziness, or lightheadedness.
  • Severe nausea, vomiting, or diarrhea.
  • Flushing, headache, or rapid heartbeats.
  • Any rash.
  • No improvement in condition or feeling worse.


How should I store this medicine?

  • Store in a tight container at room temperature.


General statements

  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).


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