|(doks oh ROO bi
|Adriamycin PFS™; Adriamycin RDF®; Rubex®|
Antineoplastic Agent, Antibiotic|
|What key warnings should I know about before taking this
- This medicine may cause damage to your heart during or after
treatment. The risk increases above a certain dose, with radiation to the chest
area, with cyclophosphamide use, or if you have a history of heart disease.
Children are at a higher risk of heart damage later on in life. Patients with
liver disease need a lower dose. This medicine can have severe effects on the
bone marrow. The bone marrow may not be able to produce the cells found in the
blood as well as it used to. This medicine may cause damage around the area it
is given if it leaks out. This would occur if the I.V. were not working
|Reasons not to take this medicine|
- If you have an allergy to doxorubicin or any other part of the
- If you have any of the following conditions: Severely weakened heart
(congestive heart failure), cardiomyopathy, a history of poor bone marrow
function causing low blood cell counts, or abnormal heartbeats called
- If you have received a full treatment with doxorubicin, idarubicin,
epirubicin, other anthracyclines, and/or daunorubicin.
- If you are pregnant.
|What is this medicine used for?|
- This medicine is a type of cancer chemotherapy for treating many
- Doxorubicin may be used alone or in combination with other cancer
|How does it work?|
- Doxorubicin kills rapidly growing cells like cancer
|How is it best taken?|
- It is given into the vein over 3-5 minutes, as a 15-60 minute infusion
or as a 24-hour infusion. Mixing the doxorubicin with another liquid and giving
it into the vein is a type of infusion.
- Doxorubicin is given in a clinic or hospital setting.
- Continue to drink lots of fluids unless told to drink less liquid by
- Given into the abdominal cavity or the bladder as a wash in certain
|What do I do if I miss a dose?|
- This medicine is given on a specific schedule. It is important not to
miss a dose unless recommended by your healthcare provider.
- Call and reschedule as soon as
|What are the precautions when taking this
- Use caution if you have liver disease. Talk with healthcare provider.
- Tell healthcare provider if you have a weakened heart called
congestive heart failure.
- Avoid aspirin, aspirin-containing products, ibuprofen or like
products, other blood thinners (warfarin, ticlopidine, clopidogrel), garlic,
ginseng, ginkgo, vitamin E. Talk with healthcare provider if you are taking any
of these products.
- You will bleed easily. Be careful. Avoid injury. Use soft toothbrush,
- Tell dentists, surgeons, and other healthcare providers about this
- Tell your healthcare provider if you have received or are receiving
- Use caution if you have liver, bile system, or gallbladder disease.
Talk with healthcare provider.
- Be cautious about taking vaccinations while you are receiving this
medicine. Certain types of vaccinations may be dangerous. Talk with healthcare
- Tell healthcare provider if you are allergic to any medicine. Make
sure to tell about the allergy and how it affected you. This includes telling
about rash; hives; itching; shortness of breath; wheezing; cough; swelling of
face, lips, tongue, throat; or any other symptoms involved.
- If you are a sexually active man, protect your partner from pregnancy.
Use birth control you can trust while taking this medicine.
- Do not use in pregnancy and do not get pregnant. Use birth control you
can trust while taking this medicine.
- Do not use if you are
|What are the common side effects of this
- Side effects may depend on the dose you receive, other treatments, the
type of cancer you have, and your overall health before getting cancer.
- Risk of infection. Avoid crowds and people with infections, colds, or
- Nausea or vomiting. Small frequent meals, frequent mouth care, sucking
hard candy, or chewing gum may help.
- Mouth and lip sores. Frequent mouth care with a soft toothbrush or
cotton swabs and rinsing your mouth may help.
- Rarely, a weakened heart called congestive heart failure.
- Rarely, other forms of cancer may occur later in life.
- Loss of hair. Normal hair growth should restart after medicine is
- Reddish urine for 1-2 days after getting medicine.
- Facial flushing.
|What should I monitor?|
- Temperature. Call healthcare provider if you have a fever.
- Check blood work. Talk with healthcare provider.
- Nutrition. Try to eat as well as possible. Talk with nutritionist if
- Follow up with healthcare
|Reasons to call healthcare provider
- Signs of a life-threatening reaction. These include wheezing;
tightness in the chest; fever; itching; bad cough; blue skin color; fits;
swelling of face, lips, tongue, throat.
- Redness, swelling, pain, tenderness, or pus where medicine is given.
- Signs and symptoms of infection.
- Unusual bleeding or bruising.
- Shortness of breath, decreased ability to walk or exercise, swelling
of feet and lower legs or fast heartbeat.
- Severe nausea, vomiting, or diarrhea.
- Unusual tiredness or weakness.
- Lightheadedness or fainting.
- Any rash.
|How should I store this medicine?|
- This medicine will be given in a clinic or hospital setting. You will
not store it at home.
- Do not share your medicine with others and do not take anyone else's
- Keep all medicine out of the reach of children and pets.
- Keep a list of all your medicines (prescription, herbal/supplements,
vitamins, over-the-counter) with you. Give this list to healthcare provider
(doctor, nurse, pharmacist, physician assistant).
- Talk with healthcare provider before starting any new medicine,
including over-the-counter or natural products (herbs,
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