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Table of Contents > Drugs >  Neomycin, Polymyxin B, and ...
Neomycin, Polymyxin B, and Hydrocortisone
Pronunciation
Brand Names
Therapeutic Categories
What is this medicine used for?
How does it work?
How is it best taken?
What do I do if I miss a dose?
What are the precautions when taking this medicine?
What are the common side effects of this medicine?
What should I monitor?
Reasons to call healthcare provider immediately
How should I store this medicine?
General statements

Pronunciation
(nee oh MYE sin, pol i MIKS in bee, & hye droe KOR ti sone)

Brand Names
AK-Spore® H.C. Otic Solution; AK-Spore® H.C. Otic Suspension; AntibiOtic® Otic; Cortatrigen® Otic; Cortisporin® Ophthalmic Suspension; Cortisporin® Otic; Cortisporin® Topical Cream; Octicair® Otic; Otic-Care® Otic; Otocort® Otic; Otosporin® Otic; PediOtic® Otic; UAD Otic®

Therapeutic Categories
Antibiotic/Corticosteroid, Ophthalmic; Antibiotic/Corticosteroid, Otic; Topical Skin Product

What is this medicine used for?

  • Neomycin and polymixin are antibiotics used to treat a variety of bacterial infections.
  • Hydrocortisone is used to reduce redness, irritation, swelling, and itching.
  • The eye drops are used in steroid-responsive inflammatory eye conditions in which hydrocortisone is indicated and where bacterial infection or a risk of bacterial infection exists.
  • The ear solution is used for the treatment of bacterial infections of the external ear canal.
  • The ear suspension is used for infections of mastoidectomy and fenestration cavities.
  • The skin cream is used to help prevent infections in minor cuts, scrapes, burns, and to treat itching, swelling, or irritation.


How does it work?

  • Neomycin inhibits metabolic activities in the bacteria.
  • Polymixin makes some of the manufacturing cells in the bacteria leaky.
  • Hydrocortisone prevents/reduces irritation and swelling.


How is it best taken?

  • Use entire prescription as directed, even if feeling better.
  • Skin:
    • Do not take by mouth. For skin only. Keep out of mouth, nose, and eyes (may burn).
    • Wash your hands before and after use.
    • Clean affected area before use.
    • Use in a small amount over the area affected as a light film. Rub in gently.
    • Do not put coverings (bandages, dressings, make-up) over the area unless told to do so by healthcare provider.
  • Eye:
    • For the eye only.
    • Shake well first.
    • Take out soft contact lenses before using medicine. Lenses can be replaced 15 minutes after medicine is given.
    • Do not touch the bottle or tube tip to the eye, lid, or other skin.
    • Tilt head back and drop medicine into eye.
    • After using medicine keep your eyes closed. Apply pressure to the inside corner of the eye. Do this for 3-5 minutes. This keeps medicine in the eye.
    • Separate each eye medicine by 5 minutes. Give one and wait 5 minutes before using the next.
  • Ear:
    • For the ear only. Shake suspension well first.
    • Wash hands before and after applying.
    • Lie on side with affected ear up.
    • For adults, hold the ear lobe up and back.
    • For children, hold ear down and back.
    • Instill drops in ear without touching dropper to ear. Stay on side for 2 minutes or insert cotton plug into ear.


What do I do if I miss a dose?

  • Apply a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
  • Do not apply a double dose or extra doses.


What are the precautions when taking this medicine?

  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.


What are the common side effects of this medicine?

  • Skin and Ear:
    • Burning, itching, redness, dryness.
  • Eye:
    • Bright lights may be irritating. Keep sunglasses with you.
    • Blurred vision. Use caution when driving, or doing tasks that need clear vision.
    • Stinging after putting drops in eye.


What should I monitor?

  • Follow up with healthcare provider.


Reasons to call healthcare provider immediately

  • Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat.
  • Any rash.
  • No improvement in condition or feeling worse.


How should I store this medicine?

  • Store at room temperature.


General statements

  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).


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