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Table of Contents > Drugs >  Doxycycline
Brand Names
Foreign Brand Names
Therapeutic Categories
Reasons not to take this medicine
What is this medicine used for?
How does it work?
How is it best taken?
What do I do if I miss a dose?
What are the precautions when taking this medicine?
What are the common side effects of this medicine?
What should I monitor?
Reasons to call healthcare provider immediately
How should I store this medicine?
General statements

(doks i SYE kleen)

Brand Names
Atridox®; Doryx® Oral; Doxy®; Monodox®; Periostat®; Vibramycin®; Vibra-Tabs®

Foreign Brand Names
Apo-Doxy® (Canada); Apo-Doxy® Tabs (Canada); Doxycin (Canada); Doxytec (Canada); Novo-Doxylin (Canada); Nu-Doxycycline (Canada); Vibramicina (Mexico)

Therapeutic Categories
Antibiotic, Tetracycline Derivative

Reasons not to take this medicine

  • If you have an allergy to any other tetracycline, doxycycline, or any other part of the medicine.
  • If you have severe liver disease.
  • Do not give to a child less than 8 years of age.

What is this medicine used for?

  • This medicine is used to prevent and to treat a variety of bacterial infections.
  • When applied to the skin, it is used for the prevention and treatment of acne.
  • The Periostat Capsule™ is used to help with adult periodontitis. It is used with scaling and root planing. It may take time to see improvement. Talk with healthcare provider.

How does it work?

  • Doxycycline inhibits the protein production in bacteria preventing them from living.

How is it best taken?

  • To gain the most benefit, do not miss doses.
  • Take with or without food. Take with food if this medicine causes stomach upset.
  • A liquid (suspension, syrup) is available if you cannot swallow pills. Those who have feeding tubes can also use the liquid. Flush the feeding tube before and after medicine is given. Shake well first. Stop tube feeding for 2 hours, flush tube, and give medication. Flush tube and restart tube feeding 1 hour later.
  • Do not take calcium, iron, magnesium, zinc, multivitamins with minerals, colestipol, cholestyramine, or didanosine within 2 hours of this medicine.
  • Do not take with aluminum-, calcium-, or magnesium-containing antacids.

What do I do if I miss a dose?

  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
  • Do not take a double dose or extra doses.

What are the precautions when taking this medicine?

  • Not to be used in children younger than 8 years of age.
  • Do not take bismuth (Pepto-Bismol®) at the same time as this medicine.
  • Avoid alcohol (includes wine, beer, and liquor). May make infection more difficult to treat.
  • You can get sunburned more easily. Avoid lots of sun. Use sunscreen; wear protective clothing and eyewear.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
  • Do not use in pregnancy and do not get pregnant. Use birth control that you can trust while taking this medicine.
  • Birth control pills may not work. Use another form of birth control while taking this medicine.
  • Tell healthcare provider if you are breast-feeding.

What are the common side effects of this medicine?

  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard candy, or chewing gum may help.
  • Belly pain and cramps.
  • Diarrhea. Yogurt, Bifidobacterium bifidum , or Lactobacillus acidophilus may help. These products are available at health food stores or in some pharmacies.
  • Vaginal irritation. Report itching or discharge to healthcare provider.
  • Side effects from Periostat ™ would be much less.

What should I monitor?

  • Watch for change in temperature or worsening of infection if you are being treated for an active infection.
  • Follow up with healthcare provider.

Reasons to call healthcare provider immediately

  • Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat.
  • Severe headache.
  • Severe nausea, vomiting, and/or diarrhea.
  • Any rash.
  • No improvement in condition or feeling worse.

How should I store this medicine?

  • Store in a tight, light-resistant container at room temperature.

General statements

  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).

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  Substances depleted by this drug
View Depletions
  Interactions with supplements
Alpha-Lipoic Acid
Ethylenediaminetetraacetic Acid (EDTA)
Vitamin H (Biotin)
Vitamin K

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