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Table of Contents > Drugs >  Acetaminophen, Isometheptene, and ...
Acetaminophen, Isometheptene, and Dichloralphenazone
Pronunciation
Brand Names
Therapeutic Categories
Reasons not to take this medicine
What is this medicine used for?
How does it work?
How is it best taken?
What do I do if I miss a dose?
What are the precautions when taking this medicine?
What are the common side effects of this medicine?
What should I monitor?
Reasons to call healthcare provider immediately
How should I store this medicine?
General statements

Pronunciation
(a seet a MIN oh fen, eye soe me THEP teen, & dye KLOR al FEN a zone)

Brand Names
Midrin®; Migratine®

Therapeutic Categories
Analgesic, Miscellaneous

Reasons not to take this medicine
  • If you have an allergy to acetaminophen, isometheptene, dichloralphenazone, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you have any of the following conditions: Glaucoma, heart disease, high blood pressure, liver disease, or poor kidney function.
  • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.

  • What is this medicine used for?
  • This medicine is used to treat headaches.

  • How does it work?
  • Acetaminophen blocks production and release of chemicals that cause pain.
  • Isometheptene may reduce headache pain.
  • Dichloralphenazone calms the brain.

  • How is it best taken?
  • Do not take more than 5 capsules a day for a migraine or 8 capsules a day for a tension headache.
  • Take this medicine with or without food. Take with food if it causes an upset stomach.

  • What do I do if I miss a dose?
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take a double dose or extra doses.
  • Many times this medicine is taken on an as needed basis. Do not take more often than every 4 hours, unless instructed by healthcare provider.

  • What are the precautions when taking this medicine?
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Avoid or limit alcohol intake (includes wine, beer, and liquor) to less than 3 drinks a day. Drinking too much alcohol may increase the risk of liver disease.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.

  • What are the common side effects of this medicine?
  • Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
  • Liver damage can rarely occur.

  • What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Follow up with healthcare provider.

  • Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Severe headache.
  • Any rash.
  • No improvement in condition or feeling worse.

  • How should I store this medicine?
  • Store at room temperature.
  • Protect from moisture. Do not store in a bathroom or kitchen.

  • General statements
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

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